Oncogenic PI3Kα promotes multipotency in breast epithelial cells

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Sci. Signal.  03 Nov 2015:
Vol. 8, Issue 401, pp. pe3
DOI: 10.1126/scisignal.aad5856

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The phosphoinositide 3-kinase (PI3K) signaling pathway is among the most frequently altered in cancer. Now, two studies show that a mutated oncogenic PI3Kα, commonly found in breast cancer, leads to dedifferentiation or destabilization of luminal and basal epithelial lineages, which in turn leads to increased cancer cell heterogeneity.

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