Editors' ChoiceInflammation

Microparticles provide protection

Sci. Signal.  01 Dec 2015:
Vol. 8, Issue 405, pp. ec360
DOI: 10.1126/scisignal.aad9393

Neutrophils play an active role in protecting cartilage from damage by dispatching microvesicles (MVs) that penetrate this tissue that is inaccessible to the neutrophils. Headland et al. found MVs present in the synovial fluid of patients with rheumatoid arthritis—an autoimmune disease that degrades cartilage in the joints. Neutrophil-derived MVs prevented damage induced by disease through a complex mechanism that involves the proresolving protein annexin A1 and its receptor. In two different mouse models of rheumatoid arthritis, MVs delivered locally entered the cartilage, prevented the loss of proteoglycans, and maintained cartilage integrity. This study suggested that immune cells protect against tissue degradation in inflammatory arthritis through the release of MVs and that MVs may be manipulated to deliver therapeutics to diseased joints.

S. E. Headland, H. R. Jones, L. V. Norling, A. Kim, P. R. Souza, E. Corsiero, C. D. Gil, A. Nerviani, F. Dell’Accio, C. Pitzalis, S. M. Oliani, L. Y. Jan, M. Perretti, Neutrophil-derived microvesicles enter cartilage and protect the joint in inflammatory arthritis. Sci. Transl. Med. 7, 315ra190 (2015). [Abstract]

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