15 December 2015
Vol 8, Issue 407

About The Cover

Cover image expansion

Online Cover This week features a Research Article that shows that the adipose tissue of obese mice contains reduced amounts of the gaseous signaling molecule hydrogen sulfide, which leads to increased production of proinflammatory cytokines by adipose tissue macrophages. However, in lean mice, hydrogen sulfide is more abundant and it suppresses calcium signaling in macrophages to limit cytokine production and inflammation. The image illustrates resident macrophages (red) in adipose tissue. [Image: K. Sutliff/Science Signaling]