Editors' ChoiceCancer

Inhibition of casein kinase 1δ reduces breast cancer

Sci. Signal.  22 Dec 2015:
Vol. 8, Issue 408, pp. ec381
DOI: 10.1126/scisignal.aaf1058

Casein kinase 1δ (CK1δ) is a protein that regulates various cellular processes, and the gene encoding this enzyme is overexpressed in a large percentage of breast and other cancers. Rosenberg et al. showed that CK1δ contributes to the growth of breast tumors by activating the transcriptional regulator β-catenin and that CK1δ can be inhibited by RNA interference or by a small-molecule drug. Treatment with a small-molecule inhibitor of CK1δ, called SR-3029, was effective at reducing the growth of breast cancer in multiple mouse models without any signs of major toxicity, suggesting that this therapeutic approach may be a good candidate for testing in human patients.

L. H. Rosenberg, M. Lafitte, V. Quereda, W. Grant, W. Chen, M. Bibian, Y. Noguchi, M. Fallahi, C. Yang, J. C. Chang, W. R. Roush, J. L. Cleveland, D. R. Duckett, Therapeutic targeting of casein kinase 1δ in breast cancer. Sci. Transl. Med. 7, 318ra202 (2015). [Abstract]