Beyond static biomarkers—The dynamic response potential of signaling networks as an alternate biomarker?

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Sci. Signal.  22 Dec 2015:
Vol. 8, Issue 408, pp. fs21
DOI: 10.1126/scisignal.aad4989

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In this week’s issue of Science Signaling, Fey et al. introduce a new type of biomarker. Using the example of neuroblastoma, the authors demonstrate that patient-specific differences in the computed property (the Hill coefficient) of the dynamics of a pathway involved in cell death signaling outperformed the prognostic capability of any single static biomarker alone or in combination.

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