Editors' ChoiceMEDICINE

Papers of note in Science Translational Medicine

Sci. Signal.  05 Jan 2016:
Vol. 9, Issue 409, pp. ec4
DOI: 10.1126/scisignal.aaf1777

Reproductive Biology

TRPing up preterm labor

TRPV4 channel activity determines myometrial tone and may be a target for treating preterm labor.

L. Ying, M. Becard, D. Lyell, X. Han, L. Shortliffe, C. I. Husted, C. M. Alvira, D. N. Cornfield, The transient receptor potential vanilloid 4 channel modulates uterine tone during pregnancy. Sci. Transl. Med. 7, 319ra204 (2015). [Abstract]

R. Smith, Reapplying the uterine brake in preterm labor. Sci. Transl. Med. 7, 319fs51 (2015). [Abstract]

Metabolic Disease

Kill the messenger

A monoclonal antibody to fatty acid–binding protein aP2 has antidiabetic effects on glucose output and utilization.

M. F. Burak, K. E. Inouye, A. White, A. Lee, G. Tuncman, E. S. Calay, M. Sekiya, A. Tirosh, K. Eguchi, G. Birrane, D. Lightwood, L. Howells, G. Odede, H. Hailu, S. West, R. Garlish, H. Neale, C. Doyle, A. Moore, G. S. Hotamisligil, Development of a therapeutic monoclonal antibody that targets secreted fatty acid–binding protein aP2 to treat type 2 diabetes. Sci. Transl. Med. 7, 319ra205 (2015). [Abstract]