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Sci. Signal.  05 Jan 2016:
Vol. 9, Issue 409, pp. ec5
DOI: 10.1126/scisignal.aaf1775


From sensing leucine to metabolic control

Structural analysis reveals how cells sense leucine to regulate metabolism.

R. L. Wolfson, L. Chantranupong, R. A. Saxton, K. Shen, S. M. Scaria, J. R. Cantor, D. M. Sabatini, Sestrin2 is a leucine sensor for the mTORC1 pathway. Science 351, 43–48 (2016). [Abstract]

C. H. S. Aylett, E. Sauer, S. Imseng, D. Boehringer, M. N. Hall, N. Ban, T. Maier, Architecture of human mTOR complex 1. Science 351, 48–52 (2016). [Abstract]

R. A. Saxton, K. E. Knockenhauer, R. L. Wolfson, L. Chantranupong, M. E. Pacold, T. Wang, T. U. Schwartz, D. M. Sabatini, Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway. Science 351, 53–58 (2016). [Abstract]

G. R. Buel, J. Blenis, Seeing mTORC1 specificity. Science 351, 25–26 (2016). [Abstract]