Editors' ChoiceImmunology

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Sci. Signal.  12 Jan 2016:
Vol. 9, Issue 410, pp. ec9
DOI: 10.1126/scisignal.aaf2150

Chemotaxis

A chemokine's sugary release

For dendritic cells to find their way to lymph nodes, the chemokine receptor CCR7 needs to have polysialic acid on it.

E. Kiermaier, C. Moussion, C. T. Veldkamp, R. Gerardy-Schahn, I. de Vries, L. G. Williams, G. R. Chaffee, A. J. Phillips, F. Freiberger, R. Imre, D. Taleski, R. J. Payne, A. Braun, R. Förster, K. Mechtler, M. Mühlenhoff, B. F. Volkman, M. Sixt, Polysialylation controls dendritic cell trafficking by regulating chemokine recognition. Science 351, 186–190 (2016). [Abstract]