19 January 2016
Vol 9, Issue 411
  • Contents

    • Research Articles

    • Editors' Choice

      • SerpinB1 improves insulin sensitivity

        A protease inhibitor secreted by the liver enables pancreatic β cells to compensate for reduced insulin sensitivity.

      • Hypoxia micromanages glioma

        Hypoxia alters microRNA biogenesis in glioma cells to promote adaptation in the tumor microenvironment.

      • Protein homeostasis limiting cancer

        A protein involved in protein homeostasis limits the maturation of IGF1R and the overproduction of blood cells.

      • Papers of note in Science Translational Medicine

        This week’s articles feature insights into diacylglycerol kinase in the immune disorder XLP-1, allergy in infants, and the neurological disease fragile X syndrome.

      • Papers of note in Science

        This week’s articles feature insights into how a micropeptide enhances muscle performance and how an energy-sensing kinase triggers mitochondrial fragmentation.

About The Cover

Cover image expansion

Online Cover This week features a Research Article that describes how aging changes the response of blood vessels to angiotensin II, thereby contributing to hypertension. The image shows a cross section of the descending aorta in a mouse that received angiotensin II. [Image: Akiyuki Nishimura/Division of Cardiocirculatory Signaling, Okazaki Institute for Integrative Bioscience (National Institute for Physiological Sciences), National Institutes of Natural Sciences, Japan]