Vol 9, Issue 413
- ABL kinases promote breast cancer osteolytic metastasis by modulating tumor-bone interactions through TAZ and STAT5 signaling
ABL kinase inhibitors could prevent breast cancer cells from breaking down bone to promote metastasis.
- Context-specific flow through the MEK/ERK module produces cell- and ligand-specific patterns of ERK single and double phosphorylation
ERK phosphorylated on a single residue of the activation motif may be a sign of dysregulated proliferation.
- The adhesion GPCR BAI1 mediates macrophage ROS production and microbicidal activity against Gram-negative bacteria
A macrophage adhesion receptor that mediates internalization of Gram-negative bacteria also stimulates the machinery that kills them.
In macrophages, an adhesion receptor both mediates phagocytosis of bacteria and triggers the generation of reactive oxygen species to kill them.