Editors' ChoiceSTRESS SIGNALING

Papers of note in Science Translational Medicine

Sci. Signal.  09 Feb 2016:
Vol. 9, Issue 414, pp. ec28
DOI: 10.1126/scisignal.aaf4008

Cancer

The more the merrier

An oligoclonal antibody overcomes drug resistance in colorectal cancers with EGFR mutations.

S. Arena, G. Siravegna, B. Mussolin, J. D. Kearns, B. B. Wolf, S. Misale, L. Lazzari, A. Bertotti, L. Trusolino, A. A. Adjei, C. Montagut, F. Di Nicolantonio, R. Nering, A. Bardelli, MM-151 overcomes acquired resistance to cetuximab and panitumumab in colorectal cancers harboring EGFR extracellular domain mutations. Sci. Transl. Med. 8, 324ra14 (2016). [Abstract]

Circadian Rhythm

For clock ticking, timing matters

Postnatal knockout of a core clock gene in mice prompts reevaluation of the systemic role of the molecular clock in the biology of aging.

G. Yang, L. Chen, G. R. Grant, G. Paschos, W.-L. Song, E. S. Musiek, V. Lee, S. C. McLoughlin, T. Grosser, G. Cotsarelis, G. A. FitzGerald, Timing of expression of the core clock gene Bmal1 influences its effects on aging and survival. Sci. Transl. Med. 8, 324ra16 (2016). [Abstract]

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