Editors' ChoiceMEDICINE

Papers of note in Science Translational Medicine

Sci. Signal.  16 Feb 2016:
Vol. 9, Issue 415, pp. ec34
DOI: 10.1126/scisignal.aaf4562


Accurin nanoparticles dutifully deliver drug

A nanoparticle formulation of an Aurora B kinase inhibitor uses ion pairing to achieve controlled release and efficacious, nontoxic target inhibition in tumors.

S. Ashton, Y. H. Song, J. Nolan, E. Cadogan, J. Murray, R. Odedra, J. Foster, P. A. Hall, S. Low, P. Taylor, R. Ellston, U. M. Polanska, J. Wilson, C. Howes, A. Smith, R. J. A. Goodwin, J. G. Swales, N. Strittmatter, Z. Takáts, A. Nilsson, P. Andren, D. Trueman, M. Walker, C. L. Reimer, G. Troiano, D. Parsons, D. De Witt, M. Ashford, J. Hrkach, S. Zale, P. J. Jewsbury, S. T. Barry, Aurora kinase inhibitor nanoparticles target tumors with favorable therapeutic index in vivo. Sci. Transl. Med. 8, 325ra17 (2016). [Abstract]

D. J. Bearss, Are Accurins the cure for Aurora kinase inhibitors? Sci. Transl. Med. 8, 325fs4 (2016). [Abstract]


Bringing atopic dermatitis up to scratch

Lack of the skin barrier protein filaggrin worsens atopic dermatitis by allergenic activation of CD1a-reactive T cells.

R. Jarrett, M. Salio, A. Lloyd-Lavery, S. Subramaniam, E. Bourgeois, C. Archer, K. L. Cheung, C. Hardman, D. Chandler, M. Salimi, D. Gutowska-Owsiak, J. B. de la Serna, P. G. Fallon, H. Jolin, A. Mckenzie, A. Dziembowski, E. I. Podobas, W. Bal, D. Johnson, D. B. Moody, V. Cerundolo, G. Ogg, Filaggrin inhibits generation of CD1a neolipid antigens by house dust mite–derived phospholipase. Sci. Transl. Med. 8, 325ra18 (2016). [Abstract]


A key to chronic pain

Interfering with the stress protein FKBP51 can block chronic pain in mice and rats, suggesting its potential as a therapeutic target.

M. Maiarù, K. K. Tochiki, M. B. Cox, L. V. Annan, C. G. Bell, X. Feng, F. Hausch, S. M. Géranton, The stress regulator FKBP51 drives chronic pain by modulating spinal glucocorticoid signaling. Sci. Transl. Med. 8, 325ra19 (2016). [Abstract]