Editorial GuideCancer

Focus Issue: Cell biology meets cancer therapy

Sci. Signal.  16 Feb 2016:
Vol. 9, Issue 415, pp. eg2
DOI: 10.1126/scisignal.aaf3386

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Cells are the targets of anticancer therapy, whether the therapy is directed at the tumor cells themselves or the cells of the immune system. Articles in this issue and in the 2015 Science Signaling archives provide insights into what makes a cell responsive to therapy and how understanding the cellular processes affected by the drugs (including endosomal trafficking and response to proteotoxic stress) can lead to personalized cancer therapies, thereby minimizing side effects and ineffective treatment strategies.

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