Vol 9, Issue 416
- Endothelial cells decode VEGF-mediated Ca2+ signaling patterns to produce distinct functional responses
A proangiogenic factor triggers proliferation or migration in endothelial cells by stimulating different calcium signaling patterns.
- Trehalose inhibits solute carrier 2A (SLC2A) proteins to induce autophagy and prevent hepatic steatosis
The disaccharide trehalose blocks glucose uptake in hepatocytes and induces autophagy that prevents fatty liver disease.
- Dynamic regulation of neutrophil polarity and migration by the heterotrimeric G protein subunits Gαi-GTP and Gβγ
Opposing effects of Gi protein α and βγ subunits on the abundance of the second messenger cAMP enable neutrophil migration.
This week’s articles feature insights into glial development, two ways calcium channels contribute to neuronal plasticity, signals that prevent T cells from reacting to food, how the microbiome supports development, and how the proteasome is regulated.