Editors' ChoiceHeart Disease

Paper of note in Science Translational Medicine

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Sci. Signal.  23 Feb 2016:
Vol. 9, Issue 416, pp. ec40
DOI: 10.1126/scisignal.aaf5025

Cardiac Hypertrophy

The missing lnc in cardiac hypertrophy

Inhibition of the long noncoding RNA Chast prevents pressure overload–induced cardiac remodeling in mice.

J. Viereck, R. Kumarswamy, A. Foinquinos, K. Xiao, P. Avramopoulos, M. Kunz, M. Dittrich, T. Maetzig, K. Zimmer, J. Remke, A. Just, J. Fendrich, K. Scherf, E. Bolesani, A. Schambach, F. Weidemann, R. Zweigerdt, L. J. de Windt, S. Engelhardt, T. Dandekar, S. Batkai, T. Thum, Long noncoding RNA Chast promotes cardiac remodeling. Sci. Transl. Med. 8, 326ra22 (2016). [Editor's Summary]