Editors' ChoiceCellular and Molecular Signaling

Papers of note in Science

Sci. Signal.  01 Mar 2016:
Vol. 9, Issue 417, pp. ec46
DOI: 10.1126/scisignal.aaf5478

Circadian Rhythms

Layered versatility atop circadian clocks

Neuropeptides enable synchronized circadian clocks to time events out of phase with the clock mechanism.

X. Liang, T. E. Holy, P. H. Taghert, Synchronous Drosophila circadian pacemakers display nonsynchronous Ca2+ rhythms in vivo. Science 351, 976–981 (2016). [Abstract]


A T cell cause for autism?

Interleukin-17–producing T cells act during gestation to induce cortical and behavioral abnormalities in offspring.

G. B. Choi, Y. S. Yim, H. Wong, S. Kim, H. Kim, S. V. Kim, C. A. Hoeffer, D. R. Littman, J. R. Huh, The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring. Science 351, 933–939 (2016). [Abstract]

M. L. Estes, A. K. McAllister, Maternal TH17 cells take a toll on baby's brain. Science 351, 919–920 (2016). [Abstract]