Editors' ChoiceMEDICINE

Paper of note in Science Translational Medicine

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Sci. Signal.  01 Mar 2016:
Vol. 9, Issue 417, pp. ec47
DOI: 10.1126/scisignal.aaf5457

Infectious Disease

Combating antibiotic resistance

A synthetic TLR-7 agonist restores immune defenses to an antibiotic-resistant pathogen lost due to antibiotic use.

M. C. Abt, C. G. Buffie, B. Sušac, S. Becattini, R. A. Carter, I. Leiner, J. W. Keith, D. Artis, L. C. Osborne, E. G. Pamer, TLR-7 activation enhances IL-22–mediated colonization resistance against vancomycin-resistant enterococcus. Sci. Transl. Med. 8, 327ra25 (2016). [Abstract]