FocusCell Biology

Properly dividing with YAP

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Sci. Signal.  01 Mar 2016:
Vol. 9, Issue 417, pp. fs3
DOI: 10.1126/scisignal.aaf2527

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Abstract

The Hippo pathway prevents organ overgrowth and maintains tissue architecture by inhibiting the transcriptional coactivator YAP. In this issue of Science Signaling, Bui et al. find a role for YAP during cytokinesis that is independent of its transcriptional activity. This function of YAP may be important for maintaining genomic stability in dividing cells.

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