Editors' ChoiceMEDICINE

Papers of note in Science Translational Medicine

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Sci. Signal.  08 Mar 2016:
Vol. 9, Issue 418, pp. ec53
DOI: 10.1126/scisignal.aaf6178

Immunotherapy

DAMPening glioma

Combining an immunogenic cell death inducer with dendritic cell immunotherapy treats high-grade glioma in a preclinical model.

A. D. Garg, L. Vandenberk, C. Koks, T. Verschuere, L. Boon, S. W. Van Gool, P. Agostinis, Dendritic cell vaccines based on immunogenic cell death elicit danger signals and T cell–driven rejection of high-grade glioma. Sci. Transl. Med. 8, 328ra27 (2016). [Abstract]

Brain Hemorrhage

Beating back damage from brain bleeding

Blocking oxygen-sensing prolyl hydroxylases in the rodent CNS enhances functional recovery after brain hemorrhage.

S. S. Karuppagounder, I. Alim, S. J. Khim, M. W. Bourassa, S. F. Sleiman, R. John, C. C. Thinnes, T.-L. Yeh, M. Demetriades, S. Neitemeier, D. Cruz, I. Gazaryan, D. W. Killilea, L. Morgenstern, G. Xi, R. F. Keep, T. Schallert, R. V. Tappero, J. Zhong, S. Cho, F. R. Maxfield, T. R. Holman, C. Culmsee, G.-H. Fong, Y. Su, G.-l. Ming, H. Song, J. W. Cave, C. J. Schofield, F. Colbourne, G. Coppola, R. R. Ratan, Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models. Sci. Transl. Med. 8, 328ra29 (2016). [Abstract]

Fibrosis

SRC shows its stripes

E527K hyperactive SRC results in megakaryocytes with increased podosome formation, thrombocytopenia, myelofibrosis, bleeding, and bone pathologies.

E. Turro, D. Greene, A. Wijgaerts, C. Thys, C. Lentaigne, T. K. Bariana, S. K. Westbury, A. M. Kelly, D. Selleslag, J. C. Stephens, S. Papadia, I. Simeoni, C. J. Penkett, S. Ashford, A. Attwood, S. Austin, T. Bakchoul, P. Collins, S. V. V. Deevi, R. Favier, M. Kostadima, M. P. Lambert, M. Mathias, C. M. Millar, K. Peerlinck, D. J. Perry, S. Schulman, D. Whitehorn, C. Wittevrongel, BRIDGE-BPD Consortium, M. DeMaeyer, A. Rendon, K. Gomez, W. N. Erber, A. D. Mumford, P. Nurden, K. Stirrups, J. R. Bradley, F. L. Raymond, M. A. Laffan, C. Van Geet, S. Richardson, K. Freson, W. H. Ouwehand, A dominant gain-of-function mutation in universal tyrosine kinase SRC causes thrombocytopenia, myelofibrosis, bleeding, and bone pathologies. Sci. Transl. Med. 8, 328ra30 (2016). [Abstract]