Editors' ChoiceCELLULAR AND MOLECULAR BIOLOGY

Papers of note in Science

Sci. Signal.  08 Mar 2016:
Vol. 9, Issue 418, pp. ec54
DOI: 10.1126/scisignal.aaf6246

Cancer Biology

Have cancer stem cells MET their match?

Tumor-initiating cells differentiate to a more benign state when treated with drugs that activate protein kinase A.

D. R. Pattabiraman, B. Bierie, K. I. Kober, P. Thiru, J. A. Krall, C. Zill, F. Reinhardt, W. L. Tam, R. A. Weinberg, Activation of PKA leads to mesenchymal-to-epithelial transition and loss of tumor-initiating ability. Science 351, aad3680 (2016). [Abstract]

Immunogenomics

Regulatory use of endogenous retroviruses

Endogenous retroviruses have sculpted the gene networks involved in the innate immune response.

E. B. Chuong, N. C. Elde, C. Feschotte, Regulatory evolution of innate immunity through co-option of endogenous retroviruses. Science 351, 1083–1087 (2016). [Abstract]

V. J. Lynch, A copy-and-paste gene regulatory network. Science 351, 1029–1030 (2016). [Abstract]

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