FocusCell Biology

Sterol hindrance of Orai activation

See allHide authors and affiliations

Sci. Signal.  08 Mar 2016:
Vol. 9, Issue 418, pp. fs4
DOI: 10.1126/scisignal.aaf2357

You are currently viewing the abstract.

View Full Text

Abstract

Orai channels at the plasma membrane mediate store-operated Ca2+ entry in response to Ca2+ depletion of the endoplasmic reticulum. Orai channels are gated by stromal-interacting molecule proteins, which act as Ca2+ sensors, and the association of these proteins is enhanced in cholesterol-rich lipid rafts. In research published in Science Signaling, Derler et al. report that cholesterol inhibits Orai function through direct association with the channel amino terminus.

View Full Text