PodcastImmunology

Science Signaling Podcast for 8 March 2016: Calcium signaling and ROS in monocytes

See allHide authors and affiliations

Sci. Signal.  08 Mar 2016:
Vol. 9, Issue 418, pp. pc6
DOI: 10.1126/scisignal.aaf4907

You are currently viewing the abstract.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Abstract

This Podcast features an interview with Ivan Bogeski, author of a Research Article that appears in this issue of Science Signaling, about ORAI calcium (Ca2+) channels and reactive oxygen species (ROS) in monocytes. Monocytes are innate immune cells that engulf bacteria and produce ROS to kill them. The production of ROS in response to bacteria requires that Ca2+ flow into the cell through hexameric channels formed by ORAI subunits. However, some ORAI subunits are sensitive to and can be inhibited by ROS. Saul et al. found that the subunit composition of ORAI channels in monocytes changes to allow the cells to sustain calcium signaling even while they are producing ROS.

Listen to Podcast

View Full Text