Vol 9, Issue 419
- Identification of IL-23p19 as an endothelial proinflammatory peptide that promotes gp130-STAT3 signaling
The cytokine subunit p19 signals alone and intracellularly to promote inflammation in endothelial cells.
- Loss of Reelin protects against atherosclerosis by reducing leukocyte–endothelial cell adhesion and lesion macrophage accumulation
Reelin in the circulation promotes vascular inflammation and atherosclerosis.
This week’s article describes a new way to kill metastatic ovarian cancer cells by inducing the production of a protein in immune cells recruited to the metastatic lesion.
This week’s articles highlight imbalanced signaling in an autism spectrum disorder and the importance of cellular dynamics in determining whether cancer cells are sensitive to therapies.