Editors' ChoiceCancer

Paper of note in Science Translational Medicine

Sci. Signal.  15 Mar 2016:
Vol. 9, Issue 419, pp. ec61
DOI: 10.1126/scisignal.aaf6623


Running rings around ovarian cancer

A cyclic prosaposin-derived peptide targets ovarian cancer cells through the fatty acid translocase CD36.

S. Wang, A. Blois, T. El Rayes, J. F. Liu, M. S. Hirsch, K. Gravdal, S. Palakurthi, D. R. Bielenberg, L. A. Akslen, R. Drapkin, V. Mittal, R. S. Watnick, Development of a prosaposin-derived therapeutic cyclic peptide that targets ovarian cancer via the tumor microenvironment. Sci. Transl. Med. 8, 329ra34 (2016). [Abstract]