Editors' ChoiceBone Biology

Papers of note in Science Translational Medicine

Sci. Signal.  22 Mar 2016:
Vol. 9, Issue 420, pp. ec67
DOI: 10.1126/scisignal.aaf7071

BONE

A surprising role for sclerostin in arthritis

Blocking the Wnt inhibitor sclerostin leads to inflammatory joint destruction through enhanced activation of TNF receptor–mediated signaling, implicating sclerostin as protective in TNFα-dependent chronic inflammation.

C. Wehmeyer, S. Frank, D. Beckmann, M. Böttcher, C. Cromme, U. König, M. Fennen, A. Held, P. Paruzel, C. Hartmann, A. Stratis, A. Korb-Pap, T. Kamradt, I. Kramer, W. van den Berg, M. Kneissel, T. Pap, B. Dankbar, Sclerostin inhibition promotes TNF-dependent inflammatory joint destruction. Sci. Transl. Med. 8, 330ra35 (2016). [Abstract]

IL-17 in skin and bones

Skin inflammation inhibits bone formation through IL-17A.

Ö. Uluçkan, M. Jimenez, S. Karbach, A. Jeschke, O. Graña, J. Keller, B. Busse,

A. L. Croxford, S. Finzel, M. Koenders, W. van den Berg, T. Schinke, M. Amling, A. Waisman, G. Schett, E. F. Wagner, Chronic skin inflammation leads to bone loss by IL-17–mediated inhibition of Wnt signaling in osteoblasts. Sci. Transl. Med. 8, 330ra37 (2016). [Abstract]

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