Editors' ChoiceCell Biology

Papers of note in Science

Sci. Signal.  22 Mar 2016:
Vol. 9, Issue 420, pp. ec68
DOI: 10.1126/scisignal.aaf7077


When enough isn't enough

An enzyme in the mouse brain hypothalamic nucleus prevents overeating.

O. Lagerlöf, J. E. Slocomb, I. Hong, Y. Aponte, S. Blackshaw, G. W. Hart, R. L. Huganir, The nutrient sensor OGT in PVN neurons regulates feeding. Science 351, 1293–1296 (2016). [Abstract]

G. J. Schwartz, A satiating signal.Science 351, 1268–1269 (2016). [Abstract]


A prostaglandin barrier to inflammation

Prostaglandin E2 prevents systemic inflammation by maintaining gut barrier integrity.

R. Duffin, R. A. O’Connor, S. Crittenden, T. Forster, C. Yu, X. Zheng, D. Smyth, C. T. Robb, F. Rossi, C. Skouras, S. Tang, J. Richards, A. Pellicoro, R. B. Weller, R. M. Breyer, D. J. Mole, J. P. Iredale, S. M. Anderton, S. Narumiya, R. M. Maizels, P. Ghazal, S. E. Howie, A. G. Rossi, C. Yao, Prostaglandin E2 constrains systemic inflammation through an innate lymphoid cell–IL-22 axis. Science 351, 1333–1338 (2016). [Abstract]


Tuft cells help contain parasites

Gut epithelial tuft cells are key players in mucosal immune responses against parasites.

M. R. Howitt, S. Lavoie, M. Michaud, A. M. Blum, S. V. Tran, J. V. Weinstock, C. A. Gallini, K. Redding, R. F. Margolskee, L. C. Osborne, D. Artis, W. S. Garrett, Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut. Science 351, 1329–1333 (2016). [Abstract]

N. Harris, The enigmatic tuft cell in immunity. Science 351, 1264–1265 (2016). [Abstract]