Contents
29 March 2016
Vol 9, Issue 421
Vol 9, Issue 421
Contents
Editorial Guide
- Leveraging signaling research to understand and treat disease
Signaling research is revealing the challenges of integrating cellular and molecular information into the complex system of the intact organism.
Research Articles
- Inhibition of the kinase WNK1/HSN2 ameliorates neuropathic pain by restoring GABA inhibition
Mice lacking the HSN2 form of the kinase WNK1 are protected from neuropathic pain due to nerve injury.
- JAK2 inhibition sensitizes resistant EGFR-mutant lung adenocarcinoma to tyrosine kinase inhibitors
JAK2 inhibitors increase the abundance of EGFR in lung cancer cells, thereby restoring the efficacy of EGFR inhibitors in resistant tumors.
Research Resource
- PLIF: A rapid, accurate method to detect and quantitatively assess protein-lipid interactions
A fluorescence-based technique for detecting protein-lipid interactions may aid development of drugs that disrupt these regulatory interactions.
Editors' Choice
- PP2A to Alzheimer’s rescue
Transgenic mice with altered methylation of PP2A reveal a new strategy for treating Alzheimer’s disease.
- Making cancer cells dependent on EGFR
Counterintuitively, alleviating negative regulation of EGFRs sensitizes cells to EGFR inhibition.
- Controlling glutamine metabolism by acetylation
Glutamine controls its own synthesis by promoting the acetylation-mediated degradation of glutamine synthetase.
- Papers of note in Science Translational Medicine
This week’s articles describe new therapeutic targets in the signaling pathways underlying inflammatory diseases.
- Papers of note in Science
This week’s articles highlight how disruption of gene neighborhoods contributes to cancer, the development of tumor neoantigens, and the evolution and visualization of transcriptional regulation.
- New connections: Setting the GABA response
In the developing brain, WNK signaling enables GABA to enhance synaptic activity, but this same effect in the spinal cord contributes to neuropathic pain.
About The Cover
Online Cover This week features a Research Resource that describes PLIF, a fluorescence-based method for quantifying protein-phosphoinositide lipid interactions. This technique is useful not just for basic research but for developing drugs that target such protein-lipid interactions. The image shows fluorescent-labeled liposomes from which a phosphoinositide interacts with a peptide. [Image: Julien Viaud, INSERM and Université Toulouse, France]