29 March 2016
Vol 9, Issue 421
  • Contents

    • Editorial Guide

    • Research Articles

      • Inhibition of the kinase WNK1/HSN2 ameliorates neuropathic pain by restoring GABA inhibition

        Mice lacking the HSN2 form of the kinase WNK1 are protected from neuropathic pain due to nerve injury.

      • JAK2 inhibition sensitizes resistant EGFR-mutant lung adenocarcinoma to tyrosine kinase inhibitors

        JAK2 inhibitors increase the abundance of EGFR in lung cancer cells, thereby restoring the efficacy of EGFR inhibitors in resistant tumors.

    • Research Resource

    • Editors' Choice

      • PP2A to Alzheimer’s rescue

        Transgenic mice with altered methylation of PP2A reveal a new strategy for treating Alzheimer’s disease.

      • Making cancer cells dependent on EGFR

        Counterintuitively, alleviating negative regulation of EGFRs sensitizes cells to EGFR inhibition.

      • Papers of note in Science

        This week’s articles highlight how disruption of gene neighborhoods contributes to cancer, the development of tumor neoantigens, and the evolution and visualization of transcriptional regulation.

      • New connections: Setting the GABA response

        In the developing brain, WNK signaling enables GABA to enhance synaptic activity, but this same effect in the spinal cord contributes to neuropathic pain.

About The Cover

Cover image expansion

Online Cover This week features a Research Resource that describes PLIF, a fluorescence-based method for quantifying protein-phosphoinositide lipid interactions. This technique is useful not just for basic research but for developing drugs that target such protein-lipid interactions. The image shows fluorescent-labeled liposomes from which a phosphoinositide interacts with a peptide. [Image: Julien Viaud, INSERM and Université Toulouse, France]