Editors' ChoiceCellular and Molecular Signaling

Papers of note in Science

Sci. Signal.  05 Apr 2016:
Vol. 9, Issue 422, pp. ec81
DOI: 10.1126/scisignal.aaf7978

IMMUNOLOGY

Dialing down allergic responses

The receptor tyrosine kinase TYRO3 dampens allergic responses and enhances immunity to intestinal worms.

P. Y. Chan, E. A. Carrera Silva, D. De Kouchkovsky, L. D. Joannas, L. Hao, D. Hu, S. Huntsman, C. Eng, P. Licona-Limón, J. S. Weinstein, D. R. Herbert, J. E. Craft, R. A. Flavell, S. Repetto, J. Correale, E. G. Burchard, D. G. Torgerson, S. Ghosh, C. V. Rothlin, The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity. Science 352, 99–103 (2016). [Abstract]

IMMUNE REGULATION

Long noncoding RNAs in inflammation

A specific RNA molecule can suppress inflammatory gene expression and may protect from gluten intolerance.

A. Castellanos-Rubio, N. Fernandez-Jimenez, R. Kratchmarov, X. Luo, G. Bhagat, P. H. R. Green, R. Schneider, M. Kiledjian, J. R. Bilbao, S. Ghosh. A long noncoding RNA associated with susceptibility to celiac disease. Science 352, 91–95 (2016). [Abstract]

M. Huarte, A lncRNA links genomic variation with celiac disease. Science 352, 43–44 (2016). [Abstract]

CELL DEATH PATHWAYS

Apoptosis, necrosis, and pyroptosis

D. Wallach, T.-B. Kang, C. P. Dillon, D. R. Green, Programmed necrosis in inflammation: Toward identification of the effector molecules. Science 352, aaf2154 (2016). [Abstract]

MITOCHONDRIAL DISEASE

Thriving on a breath of low oxygen

Chronic exposure to low oxygen levels improves the health and extends the survival of mice that model a human mitochondrial disease.

I. H. Jain, L. Zazzeron, R. Goli, K. Alexa, S. Schatzman-Bone, H. Dhillon, O. Goldberger, J. Peng, O. Shalem, N. E. Sanjana, F. Zhang, W. Goessling, W. M. Zapol, V. K. Mootha, Hypoxia as a therapy for mitochondrial disease. Science 352, 54–61 (2016). [Abstract]

E. A. Shoubridge, Mitochondrial disease therapy from thin air? Science 352, 31–32 (2016).[Abstract]

SYNTHETIC BIOLOGY

Programming circuitry for synthetic biology

A programming language is devised for biological regulatory circuits.

A. A. K. Nielsen, B. S. Der, J. Shin, P. Vaidyanathan, V. Paralanov, E. A. Strychalski, D. Ross, D. Densmore, C. A. Voigt, Genetic circuit design automation. Science 352, aac7341 (2016). [Abstract]

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