Editors' ChoiceSignal Transduction

Papers of note in Science

Sci. Signal.  12 Apr 2016:
Vol. 9, Issue 423, pp. ec87
DOI: 10.1126/scisignal.aaf8405

CANCER

Macrophages block tumors' spread

Lymph node macrophages provide a physical barrier against tumor spread.

F. Pucci, C. Garris, C. P. Lai, A. Newton, C. Pfirschke, C. Engblom, D. Alvarez, M. Sprachman, C. Evavold, A. Magnuson, U. H. von Andrian, K. Glatz, X. O. Breakefield, T. R. Mempel, R. Weissleder, M. J. Pittet, SCS macrophages suppress melanoma by restricting tumor-derived vesicle–B cell interactions. Science 352, 242–246 (2016). [Abstract]

CANCER BIOLOGY

Oncogene control of antitumor immunity

Aberrant activation of the MYC gene helps tumor cells evade the immune response.

S. C. Casey, L. Tong, Y. Li, R. Do, S. Walz, K. N. Fitzgerald, A. M. Gouw, V. Baylot, I. Gütgemann, M. Eilers, D. W. Felsher, MYC regulates the antitumor immune response through CD47 and PD-L1. Science 352, 227–231 (2016). [Abstract]

TRANSCRIPTION

How bacteria switch between tracks

A powerful technique is described for discovering riboswitches and attenuators that respond to previously unknown ligands.

D. Dar, M. Shamir, J. R. Mellin, M. Koutero, N. Stern-Ginossar, P. Cossart, R. Sorek, Term-seq reveals abundant ribo-regulation of antibiotics resistance in bacteria. Science 352, aad9822 (2016). [Abstract]

M. O. A. Sommer, B. Suess, (Meta-)genome mining for new ribo-regulators. Science 352, 144–145 (2016). [Abstract]

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