Editors' ChoiceMEDICINE

Papers of note in Science Translational Medicine

Sci. Signal.  19 Apr 2016:
Vol. 9, Issue 424, pp. ec93
DOI: 10.1126/scisignal.aaf8876


Adding fuel to a cancer fire

Antioxidant antidiabetic drugs may promote tumor metastasis.

H. Wang, X. Liu, M. Long, Y. Huang, L. Zhang, R. Zhang, Y. Zheng, X. Liao, Y. Wang, Q. Liao, W. Li, Z. Tang, Q. Tong, X. Wang, F. Fang, M. R. de la Vega, Q. Ouyang, D. D. Zhang, S. Yu, H. Zheng, NRF2 activation by antioxidant antidiabetic agents accelerates tumor metastasis. Sci. Transl. Med. 8, 334ra51 (2016). [Abstract]

Playing with JAKs

JAK2 amplification decreases survival in triple-negative breast cancer but can be targeted with JAK2-specific inhibitors.

J. M. Balko, L. J. Schwarz, N. Luo, M. V. Estrada, J. M. Giltnane, D. Dávila-González, K. Wang, V. Sánchez, P. T. Dean, S. E. Combs, D. Hicks, J. A. Pinto, M. D. Landis, F. D. Doimi, R. Yelensky, V. A. Miller, P. J. Stephens, D. L. Rimm, H. Gómez, J. C. Chang, M. E. Sanders, R. S. Cook, C. L. Arteaga, Triple-negative breast cancers with amplification of JAK2 at the 9p24 locus demonstrate JAK2-specific dependence. Sci. Transl. Med. 8, 334ra53 (2016). [Abstract]


Postmenopausal muscle and mitochondrial mayhem

ERα action in skeletal muscle is involved in the preservation of mitochondrial health and insulin sensitivity in female mice and can serve as a defense against metabolic disease in women.

V. Ribas, B. G. Drew, Z. Zhou, J. Phun, N. Y. Kalajian, T. Soleymani, P. Daraei, K. Widjaja, J. Wanagat, T. Q. de Aguiar Vallim, A. H. Fluitt, S. Bensinger, T. Le, C. Radu, J. P. Whitelegge, S. W. Beaven, P. Tontonoz, A. J. Lusis, B. W. Parks, L. Vergnes, K. Reue, H. Singh, J. C. Bopassa, L. Toro, E. Stefani, M. J. Watt, S. Schenk, T. Akerstrom, M. Kelly, B. K. Pedersen, S. C. Hewitt, K. S. Korach, A. L. Hevener, Skeletal muscle action of estrogen receptor α is critical for the maintenance of mitochondrial function and metabolic homeostasis in females. Sci. Transl. Med. 8, 334ra54 (2016). [Abstract]