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Computational spatiotemporal analysis identifies WAVE2 and cofilin as joint regulators of costimulation-mediated T cell actin dynamics

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Sci. Signal.  19 Apr 2016:
Vol. 9, Issue 424, pp. rs3
DOI: 10.1126/scisignal.aad4149

Article Information

vol. 9 no. 424 rs3

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History: 
  • Received September 10, 2015
  • Accepted April 1, 2016

Author Information

  1. Kole T. Roybal1,2,*,,
  2. Taráz E. Buck3,,
  3. Xiongtao Ruan3,,
  4. Baek Hwan Cho3,,
  5. Danielle J. Clark1,
  6. Rachel Ambler1,
  7. Helen M. Tunbridge1,
  8. Jianwei Zhang3,§,
  9. Paul Verkade4,
  10. Christoph Wülfing1,2,5,||, and
  11. Robert F. Murphy3,6,7,||
  1. 1School of Cellular and Molecular Medicine, University of Bristol, Bristol BS8 1TD, UK.
  2. 2Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  3. 3Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
  4. 4School of Biochemistry, University of Bristol, Bristol BS8 1TD, UK.
  5. 5Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  6. 6Departments of Biological Sciences, Biomedical Engineering, and Machine Learning, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
  7. 7Freiburg Institute for Advanced Studies and Faculty of Biology, Albert Ludwig University of Freiburg, Freiburg im Breisgau 79104, Baden-Württemberg, Germany.
  1. ||Corresponding author. E-mail: christoph.wuelfing{at}bristol.ac.uk (C.W.); murphy{at}cmu.edu (R.F.M.)
  • * Present address: University of California, San Francisco, 600 16th Street, San Francisco, CA 94158, USA.

  • These authors contributed equally to this work.

  • Present address: Samsung Advanced Institute of Technology, 130 Samsung-ro, Yeongtong-gu, Suwon-si, Gyeonggi-do, 443-803, Korea.

  • § Present address: School of Computer Science and Engineering, South China University of Technology, Guangzhou Higher Education Mega Center, Panyu District, Guangzhou, Guangdong 510000, China.

  • Joint senior authors.

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