Editors' ChoiceMEDICINE

Papers of note in Science Translational Medicine

Sci. Signal.  26 Apr 2016:
Vol. 9, Issue 425, pp. ec99
DOI: 10.1126/scisignal.aaf9338


Antibody TIEs sepsis up in knots

Vascular protection through TIE2 activation is a potential treatment strategy to ameliorate sepsis.

S. Han, S.-J. Lee, K. E. Kim, H. S. Lee, N. Oh, I. Park, E. Ko, S. J. Oh, Y.-S. Lee, D. Kim, S. Lee, D. H. Lee, K.-H. Lee, S. Y. Chae, J.-H. Lee, S.-J. Kim, H.-C. Kim, S. Kim, S. H. Kim, C. Kim, Y. Nakaoka, Y. He, H. G. Augustin, J. Hu, P. H. Song, Y.-I. Kim, P. Kim, I. Kim, G. Y. Koh, Amelioration of sepsis by TIE2 activation–induced vascular protection. Sci. Transl. Med. 8, 335ra55 (2016). [Abstract]

S. M. Parikh, Targeting Tie2 and the host vascular response in sepsis. Sci. Transl. Med. 8, 335fs9 (2016). [Abstract]


A gain in pain control

A selective Nav1.7 sodium channel blocker reduced hyperexcitability of iPSC-derived sensory neurons and alleviated pain in a subpopulation of patients with an inherited pain disorder.

L. Cao, A. McDonnell, A. Nitzsche, A. Alexandrou, P.-P. Saintot, A. J.C. Loucif, A. R. Brown, G. Young, M. Mis, A. Randall, S. G. Waxman, P. Stanley, S. Kirby, S. Tarabar, A. Gutteridge, R. Butt, R. M. McKernan, P. Whiting, Z. Ali, J. Bilsland, E. B. Stevens, Pharmacological reversal of a pain phenotype in iPSC-derived sensory neurons and patients with inherited erythromelalgia. Sci. Transl. Med. 8, 335ra56 (2016). [Abstract]