Editors' ChoiceMEDICINE

Papers of note in Science Translational Medicine

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Sci. Signal.  03 May 2016:
Vol. 9, Issue 426, pp. ec106
DOI: 10.1126/scisignal.aaf9804

INFECTIOUS DISEASE

Beyond antibiotics

Interferon regulatory factor 7 is an innate immune target for non–antibiotic-based immunotherapy for bacterial infection.

M. Puthia, I. Ambite, C. Cafaro, D. Butler, Y. Huang, N. Lutay, G. Rydström, B. Gullstrand, B. Swaminathan, A. Nadeem, B. Nilsson, C. Svanborg, IRF7 inhibition prevents destructive innate immunity—A target for nonantibiotic therapy of bacterial infections. Sci. Transl. Med. 8, 336ra59 (2016). [Abstract]

FRAGILE X SYNDROME

MDM2 inhibitor rescues fragile X deficits

The MDM2 inhibitor Nutlin-3 rescues neurogenic and cognitive deficits in mice with fragile X syndrome.

Y. Li, M. E. Stockton, I. Bhuiyan, B. E. Eisinger, Y. Gao, J. L. Miller, A. Bhattacharyya, X. Zhao, MDM2 inhibition rescues neurogenic and cognitive deficits in a mouse model of fragile X syndrome. Sci. Transl. Med. 8, 336ra61 (2016).[Abstract]