Papers of note in Science

Sci. Signal.  03 May 2016:
Vol. 9, Issue 426, pp. ec107
DOI: 10.1126/scisignal.aaf9803


Progesterone signaling in sperm

The ABHD2 progesterone receptor cleaves a membrane endocannabinoid to activate the CatSper calcium channel in sperm.

M. R. Miller, N. Mannowetz, A. T. Iavarone, R. Safavi, E. O. Gracheva, J. F. Smith, R. Z. Hill, D. M. Bautista, Y. Kirichok, P. V. Lishko, Unconventional endocannabinoid signaling governs sperm activation via the sex hormone progesterone. Science 352, 555–559 (2016). [Abstract]


Phase separation organizes signaling

Phosphorylation-regulated molecular aggregation promotes signaling.

X. Su, J. A. Ditlev, E. Hui, W. Xing, S. Banjade, J. Okrut, D. S. King, J. Taunton, M. K. Rosen, R. D. Vale, Phase separation of signaling molecules promotes T cell receptor signal transduction. Science 352, 595–599 (2016). [Abstract]

M. L. Dustin, J. Muller, Liquidity in immune cell signaling. Science 352, 516–517 (2016). [Abstract]


Synthetic twists among lipids

The effect of photoisomerization on global conformation of a synthetic compound embedded in a lipid bilayer is probed by nuclear magnetic resonance spectroscopy.

M. De Poli, W. Zawodny, O. Quinonero, M. Lorch, S. J. Webb, J. Clayden, Conformational photoswitching of a synthetic peptide foldamer bound within a phospholipid bilayer. Science 352, 575–580 (2016). [Abstract]

C. M. Thiele, A. S. Ulrich, Light flips a membrane-embedded helix. Science 352, 520 (2016). [Abstract]


Signaling at the synapse

Crystal structures reveal organizational features of the central mediators of rapid neurotransmission and synaptic plasticity.

B. Herguedas, J. García-Nafría, O. Cais, R. Fernández-Leiro, J. Krieger, H. Ho, I. H. Greger, Structure and organization of heteromeric AMPA-type glutamate receptors. Science 352, aad3873 (2016). [Abstract]

Sleep induction through ion changes

In mice, extracellular ion concentrations in the brain can change quickly and induce switches from sleep to wakefulness.

F. Ding, J. O’Donnell, Q. Xu, N. Kang, N. Goldman, M. Nedergaard, Changes in the composition of brain interstitial ions control the sleep-wake cycle. Science 352, 550–555 (2016). [Abstract]

H.-P. Landolt, S. C. Holst, Ionic control of sleep and wakefulness. Science 352, 517–518 (2016). [Summary]


Parasitic worms affect gut microbes

Intestinal helminths affect gut microbe composition and influence susceptibility to inflammatory bowel disease.

D. Ramanan, R. Bowcutt, S. C. Lee, M. S. Tang, Z. D. Kurtz, Y. Ding, K. Honda, W. C. Gause, M. J. Blaser, R. A. Bonneau, Y. A.L. Lim, P. Loke, K. Cadwell, Helminth infection promotes colonization resistance via type 2 immunity. Science 352, 608–612 (2016). [Abstract]