Editors' ChoiceCELLULAR AND MOLECULAR BIOLOGY

Papers of note in Science

Sci. Signal.  10 May 2016:
Vol. 9, Issue 427, pp. ec111
DOI: 10.1126/scisignal.aag0550

NEUROSCIENCE

Too much cleaning up

The immune complement system also attacks brain synapses early in Alzheimer’s disease mouse models.

S. Hong, V. F. Beja-Glasser, B. M. Nfonoyim, A. Frouin, S. Li, S. Ramakrishnan, K. M. Merry, Q. Shi, A. Rosenthal, B. A. Barres, C. A. Lemere, D. J. Selkoe, B. Stevens, Complement and microglia mediate early synapse loss in Alzheimer mouse models. Science 352, 712–716 (2016). [Abstract]

Faulty channels, not faulty synapses

SHANK3 mutations linked to autism spectrum disorders disrupt neuronal ion balance.

F. Yi, T. Danko, S. C. Botelho, C. Patzke, C. Pak, M. Wernig, T. C. Südhof, Autism-associated SHANK3 haploinsufficiency causes Ih channelopathy in human neurons. Science 352, aaf2669 (2016). [Abstract]

PROTEIN DESIGN

Building new proteins from the old

A design strategy builds new protein structures by recombining pieces of existing protein domains.

T. M. Jacobs, B. Williams, T. Williams, X. Xu, A. Eletsky, J. F. Federizon, T. Szyperski, B. Kuhlman, Design of structurally distinct proteins using strategies inspired by evolution. Science 352, 687–690 (2016). [Abstract]

Building with designed proteins

Protein oligomers with designed arrays of hydrogen bond networks enable programming of interaction specificity.

S. E. Boyken, Z. Chen, B. Groves, R. A. Langan, G. Oberdorfer, A. Ford, J. M. Gilmore, C. Xu, F. DiMaio, J. H. Pereira, B. Sankaran, G. Seelig, P. H. Zwart, D. Baker, De novo design of protein homo-oligomers with modular hydrogen-bond network–mediated specificity. Science 352, 680–687 (2016). [Abstract]

R. Netzer, S. J. Fleishman, Inspired by nature. Science 352, 657–658 (2016). [Abstract]

NUCLEAR BIOLOGY

Deciphering the histone code

Determining the location and epigenetic modification state of individual nucleosomes will help unpick the “histone code.”

E. Shema, D. Jones, N. Shoresh, L. Donohue, O. Ram, B. E. Bernstein, Single-molecule decoding of combinatorially modified nucleosomes. Science 352, 717–721 (2016). [Abstract]

The nongenetic roles of the nucleus

M. Bustin, T. Misteli, Nongenetic functions of the genome. Science 352, aad6933 (2016). [Abstract]

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