Papers of note in Science

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Sci. Signal.  17 May 2016:
Vol. 9, Issue 428, pp. ec118
DOI: 10.1126/scisignal.aag1292


A recipe for intestinal lgA

Multiple cellular and molecular cues in the intestine instruct B cells to switch to producing immunoglobulin A.

A. Reboldi, T. I. Arnon, L. B. Rodda, A. Atakilit, D. Sheppard, J. G. Cyster, IgA production requires B cell interaction with subepithelial dendritic cells in Peyer’s patches. Science 352, aaf4822 (2016). [Abstract]


An oncohistone deranges inhibitory chromatin

The lysine-36–to–methionine mutation in histone H3 is oncogenic and interferes with inhibitory chromatin marks.

C. Lu, S. U. Jain, D. Hoelper, D. Bechet, R. C. Molden, L. Ran, D. Murphy, S. Venneti, M. Hameed, B. R. Pawel, J. S. Wunder, B. C. Dickson, S. M. Lundgren, K. S. Jani, N. De Jay, S. Papillon-Cavanagh, I. L. Andrulis, S. L. Sawyer, D. Grynspan, R. E. Turcotte, J. Nadaf, S. Fahiminiyah, T. W. Muir, J. Majewski, C. B. Thompson, P. Chi, B. A. Garcia, C. D. Allis, N. Jabado, P. W. Lewis, Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape. Science 352, 844–849 (2016). [Abstract]