Editors' ChoiceCellular and Molecular Signaling

Papers of note in Science

Sci. Signal.  24 May 2016:
Vol. 9, Issue 429, pp. ec125
DOI: 10.1126/scisignal.aag1804


Another pathway to cancer resistance

Brain tumors can acquire resistance to therapy through changes to their microenvironment.

D. F. Quail, R. L. Bowman, L. Akkari, M. L. Quick, A. J. Schuhmacher, J. T. Huse, E. C. Holland, J. C. Sutton, J. A. Joyce, The tumor microenvironment underlies acquired resistance to CSF-1R inhibition in gliomas. Science 352, aad3018 (2016). [Abstract]


Insights into antibody therapy for HIV-1

Clinical and animal data confirm that HIV-1 immunotherapy boosts infected cell clearance and immune responses against the virus.

T. Schoofs, F. Klein, M. Braunschweig, E. F. Kreider, A. Feldmann, L. Nogueira, T. Oliveira, J. C. C. Lorenzi, E. H. Parrish, G. H. Learn, A. P. West Jr., P. J. Bjorkman, S. J. Schlesinger, M. S. Seaman, J. Czartoski, M. J. McElrath, N. Pfeifer, B. H. Hahn, M. Caskey, M. C. Nussenzweig, HIV-1 therapy with monoclonal antibody 3BNC117 elicits host immune responses against HIV-1. Science 352, 997–1001 (2016). [Abstract]

C.-L. Lu, D. K. Murakowski, S. Bournazos, T. Schoofs, D. Sarkar, A. Halper-Stromberg, J. A. Horwitz, L. Nogueira, J. Golijanin, A. Gazumyan, J. V. Ravetch, M. Caskey, A. K. Chakraborty, M. C. Nussenzweig, Enhanced clearance of HIV-1–infected cells by broadly neutralizing antibodies against HIV-1 in vivo. Science 352, 1001–1004 (2016). [Abstract]


Synapse identity through specific splicing

The RNA binding protein SLM2 directs the splice isoform identity of synaptic recognition receptors.

L. Traunmüller, A. M. Gomez, T.-M. Nguyen, P. Scheiffele, Control of neuronal synapse specification by a highly dedicated alternative splicing program. Science 352, 982–986 (2016). [Abstract]


A starvation survival signal fights DNA damage

The bacterial alarmone ppGpp promotes DNA repair by shunting the transcription machinery away from DNA damage.

V. Kamarthapu, V. Epshtein, B. Benjamin, S. Proshkin, A. Mironov, M. Cashel, E. Nudler, ppGpp couples transcription to DNA repair in E. coli. Science 352, 993–996 (2016). [Abstract]


Peptide domain links phosphate need to uptake

A conserved peptide domain allows a cell to sense how much phosphate it has and regulate uptake of more phosphate if needed.

R. Wild, R. Gerasimaite, J.-Y. Jung, V. Truffault, I. Pavlovic, A. Schmidt, A. Saiardi, H. J. Jessen, Y. Poirier, M. Hothorn, A. Mayer, Control of eukaryotic phosphate homeostasis by inositol polyphosphate sensor domains. Science 352, 986–990 (2016). [Abstract]


The secrets of making signaling responsive

How binding of multiple ligands to receptors shapes dose responses.

S. H. Ha, J. E. Ferrell Jr., Thresholds and ultrasensitivity from negative cooperativity. Science 352, 990–993 (2016). [Abstract]