FocusPhysiology

Forget about thrombosis: Platelets and Alzheimer’s disease, yet another sticky situation

Sci. Signal.  24 May 2016:
Vol. 9, Issue 429, pp. fs9
DOI: 10.1126/scisignal.aaf8702

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Abstract

In this issue of Science Signaling, Donner et al. define a highly interesting role for platelets in mediating the pathogenesis of Alzheimer’s disease via a mechanism linked to integrin αIIbβ3 outside-in signaling and adenosine diphosphate release. These findings raise the intriguing prospect of harnessing antiplatelet drugs for disrupting the nexus between Aβ-induced activated platelets and Aβ fibril and aggregate formation.

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