Editors' ChoiceMEDICINE

Papers of note in Science Translational Medicine

Sci. Signal.  31 May 2016:
Vol. 9, Issue 430, pp. ec130
DOI: 10.1126/scisignal.aag2217


Rehabilitation of a β-amyloid bad boy

β-Amyloid protein, a contributor to Alzheimer’s disease, may play a physiological role in microbial entrapment and innate immunity.

D. K. V. Kumar, S. H. Choi, K. J. Washicosky, W. A. Eimer, S. Tucker, J. Ghofrani, A. Lefkowitz, G. McColl, L. E. Goldstein, R. E. Tanzi, R. D. Moir, Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer’s disease. Sci. Transl. Med. 8, 340ra72 (2016). [Abstract]


Taking away cancer’s hideouts

Breast cancer cells traffic to and from the peripheral blood within specific vascular niches, and this migration can be therapeutically targeted.

T. T. Price, M. L. Burness, A. Sivan, M. J. Warner, R. Cheng, C. H. Lee, L. Olivere, K. Comatas, J. Magnani, H. K. Lyerly, Q. Cheng, C. M. McCall, D. A. Sipkins, Dormant breast cancer micrometastases reside in specific bone marrow niches that regulate their transit to and from bone. Sci. Transl. Med. 8, 340ra73 (2016). [Abstract]


Rhythm remodeling traced to tiny RNA

Atrial microRNA-31 up-regulation causes dystrophin and nNOS depletion, which contributes to atrial fibrillation.

S. N. Reilly, X. Liu, R. Carnicer, A. Recalde, A. Muszkiewicz, R. Jayaram, M. C. Carena, R. Wijesurendra, M. Stefanini, N. C. Surdo, O. Lomas, C. Ratnatunga, R. Sayeed, G. Krasopoulos, T. Rajakumar, A. Bueno-Orovio, S. Verheule, T. A. Fulga, B. Rodriguez, U. Schotten, B. Casadei, Up-regulation of miR-31 in human atrial fibrillation begets the arrhythmia by depleting dystrophin and neuronal nitric oxide synthase. Sci. Transl. Med. 8, 340ra74 (2016). [Abstract]