FocusImmunology

4E-BP2 hardwires lymphocytes for rapamycin sensitivity

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Sci. Signal.  31 May 2016:
Vol. 9, Issue 430, pp. fs10
DOI: 10.1126/scisignal.aaf8190

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Abstract

The mTORC1 [mammalian (or mechanistic) target of rapamycin complex 1] inhibitor rapamycin is a potent inhibitor of T and B lymphocyte growth and proliferation. In this issue of Science Signaling, So et al. found that the isoform of 4E-BP (4E-BP2) in lymphocytes that regulates messenger RNA translation is more sensitive to the effects of rapamycin than is the 4E-BP isoform found in nonlymphoid cells. Furthermore, inhibition of 4E-BP2 blocks both the growth and proliferation of lymphocytes.

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