Editors' ChoiceCellular and Molecular Signaling

Papers of note in Science

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Sci. Signal.  07 Jun 2016:
Vol. 9, Issue 431, pp. ec135
DOI: 10.1126/scisignal.aag2797

INNATE IMMUNITY

Immune activation in context

Oxidized phospholipids released from dying cells shape dendritic cell immunity.

I. Zanoni, Y. Tan, M. Di Gioia, A. Broggi, J. Ruan, J. Shi, C. A. Donado, F. Shao, H. Wu, J. R. Springstead, J. C. Kagan, An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells. Science 352, 1232–1236 (2016). [Abstract]

B. A. Napier, D. M. Monack, A lipid arsenal to control inflammation. Science 352, 1173–1174 (2016). [Abstract]

CELL REPROGRAMMING

Making cardiac cells from fibroblasts

Heartlike cells can be generated from human skin cells using small molecules and without genetic manipulation.

N. Cao, Y. Huang, J. Zheng, C. I. Spencer, Y. Zhang, J.-D. Fu, B. Nie, M. Xie, M. Zhang, H. Wang, T. Ma, T. Xu, G. Shi, D. Srivastava, S. Ding, Conversion of human fibroblasts into functional cardiomyocytes by small molecules. Science 352, 1216–1220 (2016). [Abstract]

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