Immune activation in context
Oxidized phospholipids released from dying cells shape dendritic cell immunity.
I. Zanoni, Y. Tan, M. Di Gioia, A. Broggi, J. Ruan, J. Shi, C. A. Donado, F. Shao, H. Wu, J. R. Springstead, J. C. Kagan, An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells. Science 352, 1232–1236 (2016). [Abstract]
B. A. Napier, D. M. Monack, A lipid arsenal to control inflammation. Science 352, 1173–1174 (2016). [Abstract]
Making cardiac cells from fibroblasts
Heartlike cells can be generated from human skin cells using small molecules and without genetic manipulation.
N. Cao, Y. Huang, J. Zheng, C. I. Spencer, Y. Zhang, J.-D. Fu, B. Nie, M. Xie, M. Zhang, H. Wang, T. Ma, T. Xu, G. Shi, D. Srivastava, S. Ding, Conversion of human fibroblasts into functional cardiomyocytes by small molecules. Science 352, 1216–1220 (2016). [Abstract]