BMP signaling turns up in fragile X syndrome: FMRP represses BMPR2

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Sci. Signal.  07 Jun 2016:
Vol. 9, Issue 431, pp. fs12
DOI: 10.1126/scisignal.aaf9571

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Fragile X syndrome is the most common inherited form of intellectual disability and results from a loss of function of the translational repressor FMRP. In this issue of Science Signaling, Kashima et al. find that FMRP binds to and represses a specific isoform of BMPR2, a type II bone morphogenetic protein (BMP) receptor. Reducing signaling through this BMP pathway reverses neuroanatomical defects observed in fragile X models.

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