Editors' ChoiceCellular and Molecular Signaling

Papers of note in Science

Sci. Signal.  21 Jun 2016:
Vol. 9, Issue 433, pp. ec148
DOI: 10.1126/scisignal.aah3741


Innate immune crosstalk in T cells

Complement and NLRP3 inflammasomes work together to promote T helper 1 cell differentiation.

G. Arbore, E. E. West, R. Spolski, A. A. B. Robertson, A. Klos, C. Rheinheimer, P. Dutow, T. M. Woodruff, Z. X. Yu, L. A. O’Neill, R. C. Coll, A. Sher, W. J. Leonard, J. Köhl, P. Monk, M. A. Cooper, M. Arno, B. Afzali, H. J. Lachmann, A. P. Cope, K. D. Mayer-Barber, C. Kemper, T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cells. Science 352, aad1210 (2016). [Abstract]


A dietary supplement protects aging muscle

A dietary supplement protects muscle stem cells and increases mouse longevity.

H. Zhang, D. Ryu, Y. Wu, K. Gariani, X. Wang, P. Luan, D. D’Amico, E. R. Ropelle, M. P. Lutolf, R. Aebersold, K. Schoonjans, K. J. Menzies, J. Auwerx, NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice. Science 352, 1436–1443 (2016). [Abstract]

L. Guarente, The resurgence of NAD+. Science 352, 1396–1397 (2016). [Abstract]