Editors' ChoiceCellular and Molecular Signaling

Papers of note in Science

Sci. Signal.  05 Jul 2016:
Vol. 9, Issue 435, pp. ec157
DOI: 10.1126/scisignal.aah4656

STRUCTURAL BIOLOGY

Stargazin and the AMPA receptor

Neuronal AMPA receptor auxiliary subunits control synaptic function through variable interaction stoichiometry and electrostatics.

E. C. Twomey, M. V. Yelshanskaya, R. A. Grassucci, J. Frank, A. I. Sobolevsky, Elucidation of AMPA receptor–stargazin complexes by cryo–electron microscopy. Science 353, 83–86 (2016). [Abstract]

POSTTRANSLATIONAL MODIFICATIONS

Mapping ADP-ribosylation by PARPs

An NAD+ analog–sensitive poly(ADP-ribose) polymerase reveals key proteins and genomic loci ADP-ribosylated by PARPs for gene regulation.

B. A. Gibson, Y. Zhang, H. Jiang, K. M. Hussey, J. H. Shrimp, H. Lin, F. Schwede, Y. Yu, W. L. Kraus, Chemical genetic discovery of PARP targets reveals a role for PARP-1 in transcription elongation. Science 353, 45–50 (2016). [Abstract]

PROTEOSTASIS

Making and maintaining a healthy proteome

A review describes how the proteostasis network within cells helps to make and maintain the proteome.

D. Balchin, M. Hayer-Hartl, F. U. Hartl, In vivo aspects of protein folding and quality control. Science 353, aac4354 (2016). [Abstract]

CENTROSOMES

Kicking out an unwanted centrosome

How and why female gametes eliminate their centrosomes during oogenesis is elucidated.

A. Pimenta-Marques, I. Bento, C. A. M. Lopes, P. Duarte, S. C. Jana, M. Bettencourt-Dias, A mechanism for the elimination of the female gamete centrosome in Drosophila melanogaster. Science 353, aaf4866 (2016). [Abstract]

RETINAL REPAIR

MANF enough for tissue repair

A conserved immune modulatory mechanism promotes retinal repair in Drosophila and mouse.

J. Neves, J. Zhu, P. Sousa-Victor, M. Konjikusic, R. Riley, S. Chew, Y. Qi, H. Jasper, D. A. Lamba, Immune modulation by MANF promotes tissue repair and regenerative success in the retina. Science 353, aaf3646 (2016). [Abstract]

E. G. Cameron, J. L. Goldberg, Promoting CNS repair. Science 353, 30–31 (2016). [Abstract]

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