Editors' ChoiceSignal Transduction

Papers of note in Science

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Sci. Signal.  12 Jul 2016:
Vol. 9, Issue 436, pp. ec162
DOI: 10.1126/scisignal.aah5198


Engineering T cells to treat autoimmunity

A proof-of-principle study indicates that engineered T cells may be an effective, targeted therapy for autoimmunity.

C. T. Ellebrecht, V. G. Bhoj, A. Nace, E. J. Choi, X. Mao, M. J. Cho, G. Di Zenzo, A. Lanzavecchia, J. T. Seykora, G. Cotsarelis, M. C. Milone, A. S. Payne, Reengineering chimeric antigen receptor T cells for targeted therapy of autoimmune disease. Science 353, 179–184 (2016). [Abstract]


Resolving a network of hubs

A mathematical framework for clustering reveals organizational features of a variety of networks.

A. R. Benson, D. F. Gleich, J. Leskovec, Higher-order organization of complex networks. Science 353, 163–166 (2016). [Abstract]

N. Pržulj, N. Malod-Dognin, Network analytics in the age of big data. Science 353, 123–124 (2016). [Abstract]

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