Editors' ChoiceMEDICINE

Paper of note in Science Translational Medicine

Sci. Signal.  19 Jul 2016:
Vol. 9, Issue 437, pp. ec166
DOI: 10.1126/scisignal.aah5673

NEURODEGENERATIVE DISEASE

Blunting the sharp end of the spear

Selective translational blockade of the CACNA1A second cistron using miRNAs may have potential for treating spinocerebellar ataxia type 6.

Y. Miyazaki, X. Du, S.-i. Muramatsu, C. M. Gomez, An miRNA-mediated therapy for SCA6 blocks IRES-driven translation of the CACNA1A second cistron. Sci. Transl. Med. 8, 347ra94 (2016). [Abstract]

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