Papers of note in Science

Sci. Signal.  19 Jul 2016:
Vol. 9, Issue 437, pp. ec167
DOI: 10.1126/scisignal.aah5672


How the ER manages mitochondrial division

Mitochondrial division and distribution depend on endoplasmic reticulum–mitochondrial contact sites.

S. C. Lewis, L. F. Uchiyama, J. Nunnari, ER-mitochondria contacts couple mtDNA synthesis with mitochondrial division in human cells. Science 353, aaf5549 (2016). [Abstract]


Epigenetic regulation in the brain

Epigenetic control of transcription influences neuronal connectivity.

Y. Yang, T. Yamada, K. K. Hill, M. Hemberg, N. C. Reddy, H. Y. Cho, A. N. Guthrie, A. Oldenborg, S. A. Heiney, S. Ohmae, J. F. Medina, T. E. Holy, A. Bonni, Chromatin remodeling inactivates activity genes and regulates neural coding. Science 353, 300–305 (2016). [Abstract]

J. D. Sweatt, Chromatin controls behavior. Science 353, 218–219 (2016). [Abstract]

Sending neural stem cells back to the garage

Neurogenesis in the hippocampus depends on stem cells returning to a quiescent state via the rapid degradation of a key activation factor.

N. Urbán, D. L. C. van den Berg, A. Forget, J. Andersen, J. A. A. Demmers, C. Hunt, O. Ayrault, F. Guillemot, Return to quiescence of mouse neural stem cells by degradation of a proactivation protein. Science 353, 292–295 (2016). [Abstract]

Transmitting signals across the synapse

A molecular bridge across excitatory synapses provides a structural framework that facilitates signaling in the cerebellum.

J. Elegheert, W. Kakegawa, J. E. Clay, N. F. Shanks, E. Behiels, K. Matsuda, K. Kohda, E. Miura, M. Rossmann, N. Mitakidis, J. Motohashi, V. T. Chang, C. Siebold, I. H. Greger, T. Nakagawa, M. Yuzaki, A. R. Aricescu, Structural basis for integration of GluD receptors within synaptic organizer complexes. Science 353, 295–299 (2016). [Abstract]