Taking action against cachexia
Muscle-directed Smad7 gene delivery prevents the loss of skeletal muscle mass and strength in mouse models of cachexia, an important contributor to poor prognosis in patients with advanced cancer.
C. E. Winbanks, K. T. Murphy, B. C. Bernardo, H. Qian, Y. Liu, P. V. Sepulveda, C. Beyer, A. Hagg, R. E. Thomson, J. L. Chen, K. L. Walton, K. L. Loveland, J. R. McMullen, B. D. Rodgers, C. A. Harrison, G. S. Lynch, P. Gregorevic, Smad7 gene delivery prevents muscle wasting associated with cancer cachexia in mice. Sci. Transl. Med. 8, 348ra98 (2016). [Abstract]