Editors' ChoiceCELLULAR AND MOLECULAR BIOLOGY

Papers of note in Science

Sci. Signal.  26 Jul 2016:
Vol. 9, Issue 438, pp. ec173
DOI: 10.1126/scisignal.aah6180

MITOCHONDRIA

Eliminating paternal mitochondria

A mitochondrial enzyme promotes the destruction and removal of sperm-derived mitochondria in nematode worm embryos.

Q. Zhou, H. Li, H. Li, A. Nakagawa, J. L. J. Lin, E.-S. Lee, B. L. Harry, R. R. Skeen-Gaar, Y. Suehiro, D. William, S. Mitani, H. S. Yuan, B.-H. Kang, D. Xue, Mitochondrial endonuclease G mediates breakdown of paternal mitochondria upon fertilization. Science 353, 394–399 (2016). [Abstract]

CANCER IMMUNOTHERAPY

Cyclin suppresses antitumor immunity

Cyclin-dependent kinase 5 expression by tumors inhibits antitumor immunity in human and mouse medulloblastoma.

R. D. Dorand, J. Nthale, J. T. Myers, D. S. Barkauskas, S. Avril, S. M. Chirieleison, T. K. Pareek, D. W. Abbott, D. S. Stearns, J. J. Letterio, A. Y. Huang, A. Petrosiute, Cdk5 disruption attenuates tumor PD-L1 expression and promotes antitumor immunity. Science 353, 399–403 (2016). [Abstract]

HIV-1 CURE

Next steps toward curing HIV-1

A review describes the next steps needed to help to develop a cure for AIDS.

D. M. Margolis, J. V. Garcia, D. J. Hazuda, B. F. Haynes, Latency reversal and viral clearance to cure HIV-1. Science 353, aaf6517 (2016). [Abstract]

SYNTHETIC BIOLOGY

Building a computing system in bacteria

Designed circuits in bacteria can record input events and alter gene expression output.

N. Roquet, A. P. Soleimany, A. C. Ferris, S. Aaronson, T. K. Lu, Synthetic recombinase-based state machines in living cells. Science 353, aad8559 (2016). [Abstract]

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