Editors' ChoiceCellular and Molecular Signaling

Papers of note in Science

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Sci. Signal.  02 Aug 2016:
Vol. 9, Issue 439, pp. ec177
DOI: 10.1126/scisignal.aah6678


Plasmid copy number promotes plague

Plasmid copy number regulates virulence and trades off growth during pathogenic Yersinia infection.

H. Wang, K. Avican, A. Fahlgren, S. F. Erttmann, A. M. Nuss, P. Dersch, M. Fallman, T. Edgren, H. Wolf-Watz, Increased plasmid copy number is essential for Yersinia T3SS function and virulence. Science 353, 492–495 (2016). [Abstract]


Resistance is not, after all, futile

Tomato plants rebuff attack by a parasitic plant upon perceiving a peptide signal from the invader.

V. Hegenauer, U. Fürst, B. Kaiser, M. Smoker, C. Zipfel, G. Felix, M. Stahl, M. Albert, Detection of the plant parasite Cuscuta reflexa by a tomato cell surface receptor. Science 353, 478–481 (2016). [Abstract]

V. Ntoukakis, S. Gimenez-Ibanez, Parasitic plants—A CuRe for what ails thee. Science 353, 442–443 (2016). [Abstract]

Spring break

Winter chilling is epigenetically translated into flowering control when a repressor binds to an intron.

J. I. Qüesta, J. Song, N. Geraldo, H. An, C. Dean, Arabidopsis transcriptional repressor VAL1 triggers Polycomb silencing at FLC during vernalization. Science 353, 485–488 (2016). [Abstract]


Mom's diet affects growth

Maternal environment induces epigenetic dynamics at ribosomal DNA in the mouse.

M. L. Holland, R. Lowe, P. W. Caton, C. Gemma, G. Carbajosa, A. F. Danson, A. A. M. Carpenter, E. Loche, S. E. Ozanne, V. K. Rakyan, Early-life nutrition modulates the epigenetic state of specific rDNA genetic variants in mice. Science 353, 495–498 (2016). [Abstract]


Making bacterial cells into a memory device

By driving the acquisition of defined CRISPR spacers, living Escherichia coli cells can be used to record molecular events within genomic DNA.

S. L. Shipman, J. Nivala, J. D. Macklis, G. M. Church, Molecular recordings by directed CRISPR spacer acquisition. Science 353, aaf1175 (2016). [Abstract]

O. Borkowski, C. Gilbert, T. Ellis, On the record with E. coli DNA. Science 353, 444–445 (2016). [Abstract]